mrna decay การใช้

• Inside cells, there is a balance between the processes of translation and mRNA decay.
• If this codon occurs prior to the EJC site, the EJC will remain bound, triggering mRNA decay.
• There has been evidence that the nonsense-mediated mRNA decay pathway participates in X chromosome dosage compensation in mammals.
• One of the variants is probably not translated because the transcript is a candidate for nonsense-mediated mRNA decay.
• This gene encodes a protein involved in nonsense-mediated mRNA decay ( NMD ) as part of the mRNA surveillance complex.
• The CsrA proteins generally bind to the Shine-Dalgarno sequence of messenger RNAs and either inhibit translation or facilitate mRNA decay.
• Nonsense mediated mRNA decay in invertebrates is postulated to be mediated by the presence of a faux 3'untranslated region ( UTR ).
• The function of this short RNA has been studied using a transcriptomic approach and kinetic analyses of target mRNA decay " in vivo ".
• P-bodies are discrete cytoplasmic mRNP granules that contain non-translating mRNA and protein from the mRNA decay pathway and from miRNA silencing machinery.
• Additional variants have been described, but they are candidates for nonsense-mediated mRNA decay ( NMD ) and are unlikely to be protein-coding.
• The read-through transcript is a candidate for nonsense-mediated mRNA decay ( NMD ), and is unlikely to produce a protein product . [ provided by RefSeq, Mar 2011 ].
• Given this, the paralogs to the helicase core of the gene are associated with transcription, nonsense-mediated mRNA decay, RNA decay, miRNA processing, RISC assembly, and pre-mRNA splicing.
• It was found that these oscillations were favoured by strong promoters coupled to efficient ribosome binding sites, tight transcriptional repression ( low'leakiness'), cooperative repression characteristics, and comparable protein and mRNA decay rates.
• In general global response to DNA damage involves expression of multiple genes responsible for postreplication repair, homologous recombination, nucleotide excision repair, DNA damage checkpoint, global transcriptional activation, genes controlling mRNA decay, and many others.
• ASF / SF2, in the presence of nonsense-mediated mRNA decay ( NMD ), favoring NMD that occurs before mRNA release from the nucleus over NMD that occurs after mRNA export from the nucleus to the cytoplasm.
• Mutations within the last coding exon of "'Notch2 "'that remove the PEST domain and escape the nonsense-mediated mRNA decay have been shown to be the main cause of the Hajdu-Cheney syndrome.
• Argonaute proteins are localized to specific regions in the cytoplasm called P-bodies ( also cytoplasmic bodies or GW bodies ), which are regions with high rates of mRNA decay; miRNA activity is also clustered in P-bodies.
• The product of this gene is a core component of the exon junction complex ( EJC ), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay ( NMD ).
• Three surveillance mechanisms are currently known to function within cells : the nonsense-mediated mRNA decay pathway ( NMD ); the Nonstop Mediated mRNA decay pathways ( NSD ); and the No-go Mediated mRNA decay pathway ( NGD ).
• Three surveillance mechanisms are currently known to function within cells : the nonsense-mediated mRNA decay pathway ( NMD ); the Nonstop Mediated mRNA decay pathways ( NSD ); and the No-go Mediated mRNA decay pathway ( NGD ).